Journal of Pharmacy and Bioallied Sciences (Jan 2012)

Triple antibiotic paste in root canal therapy

  • Rangasamy Vijayaraghavan,
  • Veerabathran Mahesh Mathian,
  • Alagappan Meenakshi Sundaram,
  • Ramachandran Karunakaran,
  • Selvaraj Vinodh

DOI
https://doi.org/10.4103/0975-7406.100214
Journal volume & issue
Vol. 4, no. 6
pp. 230 – 233

Abstract

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The success of the endodontic treatment depends on the microbial suppression in the root canal and periapical region. Endodontic instrumentation alone cannot achieve a sterile condition. With the advent of non-instrumentation endodontic treatment and lesion sterilization and tissue repair, local application of antibiotics has been investigated. Triple antibiotic paste (TAP) containing metronidazole, ciprofloxacin, and minocycline has been reported to be a successful regimen in controlling the root canal pathogen and in managing non-vital young permanent tooth. This paper reviews the existing literature on biocompatibility, efficiency, drawbacks of TAP in endodontic therapy and pulp revascularization.

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