Nature Communications (Jun 2017)
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
- Xuekun Li,
- Bing Yao,
- Li Chen,
- Yunhee Kang,
- Yujing Li,
- Ying Cheng,
- Liping Li,
- Li Lin,
- Zhiqin Wang,
- Mengli Wang,
- Feng Pan,
- Qing Dai,
- Wei Zhang,
- Hao Wu,
- Qiang Shu,
- Zhaohui Qin,
- Chuan He,
- Mingjiang Xu,
- Peng Jin
Affiliations
- Xuekun Li
- The Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang University
- Bing Yao
- Department of Human Genetics, Emory University School of Medicine
- Li Chen
- Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
- Yunhee Kang
- Department of Human Genetics, Emory University School of Medicine
- Yujing Li
- Department of Human Genetics, Emory University School of Medicine
- Ying Cheng
- Department of Human Genetics, Emory University School of Medicine
- Liping Li
- The Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang University
- Li Lin
- Guangdong-Hongkong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration, Ministry of Education of PRC, Jinan University
- Zhiqin Wang
- Department of Human Genetics, Emory University School of Medicine
- Mengli Wang
- Department of Human Genetics, Emory University School of Medicine
- Feng Pan
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Qing Dai
- Department of Chemistry, University of Chicago
- Wei Zhang
- College of Business, Iowa State University
- Hao Wu
- Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
- Qiang Shu
- The Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang University
- Zhaohui Qin
- Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University
- Chuan He
- Department of Chemistry, University of Chicago
- Mingjiang Xu
- Department of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
- Peng Jin
- The Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang University
- DOI
- https://doi.org/10.1038/ncomms15903
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Epigenetic modifications, such as DNA methylation, play an important role in adult neurogenesis. Here the authors show that Tet2, which converts 5mC to 5hmC, interacts with the transcription factor Foxo3a and regulates critical genes related to the proliferation and differentiation of adult neural stem cells.
