Nature Communications (Mar 2019)

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

  • Amy H. Lee,
  • Casey P. Shannon,
  • Nelly Amenyogbe,
  • Tue B. Bennike,
  • Joann Diray-Arce,
  • Olubukola T. Idoko,
  • Erin E. Gill,
  • Rym Ben-Othman,
  • William S. Pomat,
  • Simon D. van Haren,
  • Kim-Anh Lê Cao,
  • Momoudou Cox,
  • Alansana Darboe,
  • Reza Falsafi,
  • Davide Ferrari,
  • Daniel J. Harbeson,
  • Daniel He,
  • Cai Bing,
  • Samuel J. Hinshaw,
  • Jorjoh Ndure,
  • Jainaba Njie-Jobe,
  • Matthew A. Pettengill,
  • Peter C. Richmond,
  • Rebecca Ford,
  • Gerard Saleu,
  • Geraldine Masiria,
  • John Paul Matlam,
  • Wendy Kirarock,
  • Elishia Roberts,
  • Mehrnoush Malek,
  • Guzmán Sanchez-Schmitz,
  • Amrit Singh,
  • Asimenia Angelidou,
  • Kinga K. Smolen,
  • The EPIC Consortium,
  • Ryan R. Brinkman,
  • Al Ozonoff,
  • Robert E. W. Hancock,
  • Anita H. J. van den Biggelaar,
  • Hanno Steen,
  • Scott J. Tebbutt,
  • Beate Kampmann,
  • Ofer Levy,
  • Tobias R. Kollmann

DOI
https://doi.org/10.1038/s41467-019-08794-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a robust developmental trajectory common to different populations.