Nature Communications (Mar 2019)
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory
- Amy H. Lee,
- Casey P. Shannon,
- Nelly Amenyogbe,
- Tue B. Bennike,
- Joann Diray-Arce,
- Olubukola T. Idoko,
- Erin E. Gill,
- Rym Ben-Othman,
- William S. Pomat,
- Simon D. van Haren,
- Kim-Anh Lê Cao,
- Momoudou Cox,
- Alansana Darboe,
- Reza Falsafi,
- Davide Ferrari,
- Daniel J. Harbeson,
- Daniel He,
- Cai Bing,
- Samuel J. Hinshaw,
- Jorjoh Ndure,
- Jainaba Njie-Jobe,
- Matthew A. Pettengill,
- Peter C. Richmond,
- Rebecca Ford,
- Gerard Saleu,
- Geraldine Masiria,
- John Paul Matlam,
- Wendy Kirarock,
- Elishia Roberts,
- Mehrnoush Malek,
- Guzmán Sanchez-Schmitz,
- Amrit Singh,
- Asimenia Angelidou,
- Kinga K. Smolen,
- The EPIC Consortium,
- Ryan R. Brinkman,
- Al Ozonoff,
- Robert E. W. Hancock,
- Anita H. J. van den Biggelaar,
- Hanno Steen,
- Scott J. Tebbutt,
- Beate Kampmann,
- Ofer Levy,
- Tobias R. Kollmann
Affiliations
- Amy H. Lee
- Department of Microbiology & Immunology, University of British Columbia
- Casey P. Shannon
- PROOF Centre of Excellence
- Nelly Amenyogbe
- Department of Experimental Medicine, University of British Columbia
- Tue B. Bennike
- Department of Pathology, Boston Children’s Hospital
- Joann Diray-Arce
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Olubukola T. Idoko
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Erin E. Gill
- Department of Microbiology & Immunology, University of British Columbia
- Rym Ben-Othman
- Department of Pediatrics, BC Children’s Hospital, University of British Columbia
- William S. Pomat
- Papua New Guinea Institute of Medical Research
- Simon D. van Haren
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Kim-Anh Lê Cao
- Statistical Genomics, School of Mathematics and Statistics, Melbourne Integrative Genomics, Centre for Systems Genomics, The University of Melbourne
- Momoudou Cox
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Alansana Darboe
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Reza Falsafi
- Department of Microbiology & Immunology, University of British Columbia
- Davide Ferrari
- Statistical Genomics, School of Mathematics and Statistics, Melbourne Integrative Genomics, Centre for Systems Genomics, The University of Melbourne
- Daniel J. Harbeson
- Department of Experimental Medicine, University of British Columbia
- Daniel He
- PROOF Centre of Excellence
- Cai Bing
- Department of Pediatrics, BC Children’s Hospital, University of British Columbia
- Samuel J. Hinshaw
- Department of Microbiology & Immunology, University of British Columbia
- Jorjoh Ndure
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Jainaba Njie-Jobe
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Matthew A. Pettengill
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Peter C. Richmond
- Division of Paediatrics, School of Medicine, University of Western Australia
- Rebecca Ford
- Papua New Guinea Institute of Medical Research
- Gerard Saleu
- Papua New Guinea Institute of Medical Research
- Geraldine Masiria
- Papua New Guinea Institute of Medical Research
- John Paul Matlam
- Papua New Guinea Institute of Medical Research
- Wendy Kirarock
- Papua New Guinea Institute of Medical Research
- Elishia Roberts
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Mehrnoush Malek
- BC Cancer Agency
- Guzmán Sanchez-Schmitz
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Amrit Singh
- PROOF Centre of Excellence
- Asimenia Angelidou
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Kinga K. Smolen
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- The EPIC Consortium
- Ryan R. Brinkman
- BC Cancer Agency
- Al Ozonoff
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Robert E. W. Hancock
- Department of Microbiology & Immunology, University of British Columbia
- Anita H. J. van den Biggelaar
- Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia Perth
- Hanno Steen
- Department of Pathology, Boston Children’s Hospital
- Scott J. Tebbutt
- PROOF Centre of Excellence
- Beate Kampmann
- Vaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine
- Ofer Levy
- Precision Vaccines Program, Division of Infectious Diseases, Boston Children’s Hospital
- Tobias R. Kollmann
- Department of Experimental Medicine, University of British Columbia
- DOI
- https://doi.org/10.1038/s41467-019-08794-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
The first week of life impacts health for all of life, but the mechanisms are little-understood. Here the authors extract multi-omic data from small volumes of blood to study the dynamic molecular changes during the first week of life, revealing a robust developmental trajectory common to different populations.
