Nature Communications (Jul 2021)

Central amygdala micro-circuits mediate fear extinction

  • Nigel Whittle,
  • Jonathan Fadok,
  • Kathryn P. MacPherson,
  • Robin Nguyen,
  • Paolo Botta,
  • Steffen B. E. Wolff,
  • Christian Müller,
  • Cyril Herry,
  • Philip Tovote,
  • Andrew Holmes,
  • Nicolas Singewald,
  • Andreas Lüthi,
  • Stéphane Ciocchi

DOI
https://doi.org/10.1038/s41467-021-24068-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs fear extinction.