Evaluation of the relation between monocyte count and angiographic thrombosis burden in patients with myocardial infarction with STEMI under PPCI treatment

Abstract

Introduction: Complete thrombotic occlusion of a major epicardial coronary artery is the common pathophysiological mechanism of acute ST-segment elevation myocardial infection (STEMI). Intravascular thrombosis is associated with poor prognosis in patients with STEMI. Methods:In this study, we enrolled 400 patients with STEMI undergoing PPCI . Based on TIMI ratings of the patients and reviewing their angiographic film, they were divided into two groups with high thrombus burden and low thrombus burden. Then, Monocytes were measured in two groups with higher and lower thrombus. Results:A total of 400 patients with STEMI (mean age of 58.71 ± 12.31, 80.5% male) who underwent PPCI enrolled in this study. There were no significant differences between the low thrombus and high thrombus group in In terms of diabetes, high blood pressure, previous history of MI and cardiac troponin levels, However, patients with high thrombus had lower EF .(p value < 0.001). Based on the multivariate analysis result, the amount of circulating monocytes during hospitalization is an independent factor in predicting the rate of thrombosis in angiography. Odds ratio= 3.099 , p value=0.019 .Analysis of the receiver-operating characteristic found an optimal monocyte count cut-off value to be ≤0.60*104 in predicting a high thrombus burden score. Conclusions: The results of the study showed that the number of monocytes is a predicator of high intracoronary thrombus burden in patients with acute STEMI and patients can be treated with antithrombotic treatments.

Keywords

• myocardial infarction
• monocytes
• percutaneous coronary intervention