Diagnostic biomarkers in Alzheimer’s disease

Emerlee Andersen; Bryce Casteigne; William Daniel Chapman; Andrew Creed; Forrest Foster; Allison Lapins; Rhonna Shatz; Russell P. Sawyer

Biomarkers in Neuropsychiatry (Dec 2021)

Diagnostic biomarkers in Alzheimer’s disease

Emerlee Andersen,
Bryce Casteigne,
William Daniel Chapman,
Andrew Creed,
Forrest Foster,
Allison Lapins,
Rhonna Shatz,
Russell P. Sawyer

Affiliations

Emerlee Andersen: Department of Neurology, Mayo Clinic, Rochester, MN, USA
Bryce Casteigne: Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA
William Daniel Chapman: Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA
Andrew Creed: Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA
Forrest Foster: Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA
Allison Lapins: Department of Neurology, University of Chicago, Chicago, IL, USA
Rhonna Shatz: Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA
Russell P. Sawyer: Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA; Corresponding author at: Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, 260 Stetson Street ML 0525, Cincinnati, OH, 45267-0525, USA.

Journal volume & issue: Vol. 5
p. 100041

Abstract

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In this review article we examine the various types of diagnostic biomarkers which are used in the early detection of Alzheimer’s disease. This review summerizes the A/T/N classification system for Alzheimer’s biomarkers and its use in the biomarker-based diagnosis of Alzheimer’s disease. Furthermore we review the use of structural MRI, 18F-FDG PET, Amyloid PET, Tau PET, cerebrospinal fluid biomarkers, and the emerging role of plasma biomarkers in the diagnosis of Alzheimer’s disease. In doing so we discuss each biomarkers correlation with pathologic findings, ability to distinguish Alzheimer’s disease from healthy aging, ability to distinguish Alzheimer’s disease from other neurodegenerative diseases, role in A/T/N classification system, and limitations of each biomarker.

Published in Biomarkers in Neuropsychiatry

ISSN: 2666-1446 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/biomarkers-in-neuropsychiatry

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Abstract

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