Nature Communications (Oct 2022)

The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics

  • Matthew Yoke Wui Ng,
  • Chara Charsou,
  • Ana Lapao,
  • Sakshi Singh,
  • Laura Trachsel-Moncho,
  • Sebastian W. Schultz,
  • Sigve Nakken,
  • Michael J. Munson,
  • Anne Simonsen

DOI
https://doi.org/10.1038/s41467-022-33933-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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The functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeostasis and respiration.