Nature Communications (Oct 2022)
The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics
Abstract
The functions of specific lipids in autophagosome biogenesis are not entirely clear. Here, the authors show that the ER protein GRAMD1C, a cholesterol transport protein, suppresses autophagy initiation and has roles in mitochondrial cholesterol homeostasis and respiration.