Quantitative analysis of pharmaceutical products by spectrophotometry in the infrared region: a practical review

Abstract

Quality control in the chemical-pharmaceutical industry to identify and quantify the active ingredient has fundamental importance to guarantee the quality of the final product. Its lack can generate irreparable consequences, and therefore its existence is extremely important. However, currently, in this process there is an ecologically correct need beyond the choice of the ideal method and the ideal conditions. This mini-review contemplates the current technological vision of pharmaceutical analysis through Green Analytical Chemistry (GAC). Green and sustainable methods have a main focus providing economic, environmental and social benefits. An example is spectrophotometry in the infrared region for quantitative purposes. The purpose of this mini-review is to show a practical guide for the quantitative analysis of raw materials and pharmaceutical products by spectrophotometry in the infrared region in order to contribute to a sustainability cycle, where the guarantee of product quality and the analytical awareness about health, time, waste generation, environment and cost coexist. A practical review for quantitative analysis by spectrophotometry in the infrared region was shown. It is useful for routine analysis of pharmaceutical products in general, and it can be used by chemical-pharmaceutical laboratories around the world.

Keywords

• spectrophotometry in the infrared region
• green analytical chemistry
• quantitative analysis
• sustainable alternative