Вестник трансплантологии и искусственных органов (Jun 2010)

MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR

  • A. V. Trailin,
  • T. N. Nikonenko,
  • A. S. Nikonenko,
  • T. I. Ostapenko,
  • N. N. Polyakov,
  • P. V. Pavlov,
  • O. D. Pokrova

DOI
https://doi.org/10.15825/1995-1191-2010-1-21-26
Journal volume & issue
Vol. 12, no. 1
pp. 21 – 26

Abstract

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The retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The endpoints were serum creatinine and glomerular filtration rate at 3, 6 and 12 months. KAG function in the first year is programmed by histological changes in all compartments of donor kidney. Influence of histological changes is time-dependent: the effect of ischemic damage shows up quickly, but disappeared after 6 months; the effect of arteriolohyalinosis and arteriosclerosis begins to show up later – since 6 months; changes in glomeruli have influence on a KAG function in 3 months and 1 year; interstitial fibrosis in cortex and medulla negatively influences KAG function on the extent of all first year. Our data argue for the necessity of «0»-biopsies examination for the prediction of KAG subsequent function.

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