Вестник трансплантологии и искусственных органов (Jun 2010)
MORPHOLOGICAL PREDICTORS OF KIDNEY ALLOGRAFT (KAG) FUNCTION DURING FIRST POSTTRANSPLANT YEAR
Abstract
The retrospective analysis of the influence of histological changes in donor kidneys on the KAG function during first year was conducted in 75 recipients of a cadaveric kidney. The state of tubuli, glomeruli, interstitium, vessels was assessed semiquantitatively in the material of «0»-biopsies. The endpoints were serum creatinine and glomerular filtration rate at 3, 6 and 12 months. KAG function in the first year is programmed by histological changes in all compartments of donor kidney. Influence of histological changes is time-dependent: the effect of ischemic damage shows up quickly, but disappeared after 6 months; the effect of arteriolohyalinosis and arteriosclerosis begins to show up later – since 6 months; changes in glomeruli have influence on a KAG function in 3 months and 1 year; interstitial fibrosis in cortex and medulla negatively influences KAG function on the extent of all first year. Our data argue for the necessity of «0»-biopsies examination for the prediction of KAG subsequent function.
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