Features of immunophenotype of pancreatic ductal adenocarcinoma

Abstract

Aim. To determine features of immunophenotype of pancreatic ductal adenocarcinoma. Methods and results. At the immunohistochemical research of biopsy and postoperative material of 120 patients with pancreatic ductal adenocarcinoma the expression levels of diagnostic markers of ductal-genesis cancer were made. Conclusion. There were shown features of immunohistochemical pattern of cytokeratins and oncoproteins expression in malignant structures of tumor, in PanIN foci, in reactive-changed ductules and in normal pancreatic tissue. Expediency of use of the immunohistochemical panel of markers to cytokeratins 7, 17, 18, 19 and 20, oncoproteins CEA, CA 125, CA 19-9 and pancreatic polypeptide for verification and differential diagnostics of pancreatic ductal adenocarcinoma is shown, and also the minimum diagnostic panel which includes CK7/19, CK20, CEA and PP is certain.

Keywords

• Pancreatic Cancer
• Immunohistochemistry