Role of antibiotic envelopes in preventing cardiac implantable electronic device infection: A meta‐analysis of 14 859 procedures

Abstract

Abstract Introduction We conducted an updated meta‐analysis assessing the role of antibiotic envelopes in preventing Cardiac implantable electronic devices (CIED)‐related infections as compared to standard infection prevention strategies. Methods A systematic search was conducted on Medline/PubMed and EMBASE/Ovid database. We used Mantel‐Haenszel method with fixed‐effect model to compute risk ratio (RR) with 95% confidence interval (CI). We also performed subgroup and trial sequential analysis on the data. Results Antibiotic envelope reduced the risk of both all infections [RR: 0.41, CI: 0.31‐0.54, P < .05, I2 = 75%, χ2 P < .05] and major infections [RR: 0.48, CI: 0.32‐0.70, P < .05, I2 = 60%, χ2 P = .04]. Conclusion Prophylactic use of antibiotic envelopes as an adjuvant therapy to standard infection prevention strategies, helps in reducing the risk of CIED infections.

Keywords

• antibiotic envelope
• cardiac implantable electronic devices