Ecological and Evolutionary Consequences of Anticancer Adaptations
Justine Boutry,
Antoine M. Dujon,
Anne-Lise Gerard,
Sophie Tissot,
Nick Macdonald,
Aaron Schultz,
Peter A. Biro,
Christa Beckmann,
Rodrigo Hamede,
David G. Hamilton,
Mathieu Giraudeau,
Beata Ujvari,
Frédéric Thomas
Affiliations
Justine Boutry
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
Antoine M. Dujon
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France; Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia France
Anne-Lise Gerard
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
Sophie Tissot
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
Nick Macdonald
Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia France
Aaron Schultz
Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia France
Peter A. Biro
Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia France
Christa Beckmann
Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia France; School of Science, Western Sydney University, Parramatta, NSW, Australia; Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, Australia
Rodrigo Hamede
School of Natural Sciences, University of Tasmania, Hobart, TAS, Australia
David G. Hamilton
School of Natural Sciences, University of Tasmania, Hobart, TAS, Australia
Mathieu Giraudeau
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France
Beata Ujvari
Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia France; School of Natural Sciences, University of Tasmania, Hobart, TAS, Australia
Frédéric Thomas
CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224–CNRS 5290–Université de Montpellier, Montpellier, France; Corresponding author
Summary: Cellular cheating leading to cancers exists in all branches of multicellular life, favoring the evolution of adaptations to avoid or suppress malignant progression, and/or to alleviate its fitness consequences. Ecologists have until recently largely neglected the importance of cancer cells for animal ecology, presumably because they did not consider either the potential ecological or evolutionary consequences of anticancer adaptations. Here, we review the diverse ways in which the evolution of anticancer adaptations has significantly constrained several aspects of the evolutionary ecology of multicellular organisms at the cell, individual, population, species, and ecosystem levels and suggest some avenues for future research.
