Microwave-assisted one-pot syntheses of 4-aminoquinazolines

Abstract

A simple, environmentally friendly, one-pot method for the synthesis of 4-aminoquinazolines using microwave irradiation has been developed. Structures of derivatives 3, 4, and 5 were confirmed by single-crystal X-ray diffraction. The in vitro cytotoxicity of each compound was investigated using an MTT assay with A549 and HepG2 cell lines to calculate half-maximal inhibitory concentrations.

Keywords

• 4-aminoquinazoline
• methodology
• microwave assisted
• one-pot syntheses