Scientific Reports (Sep 2018)
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria
- Brenda A. Kwambana-Adams,
- Rahab C. Amaza,
- Catherine Okoi,
- Murtala Rabiu,
- Archibald Worwui,
- Ebenezer Foster-Nyarko,
- Bernard Ebruke,
- Abdul K. Sesay,
- Madikay Senghore,
- Abdullahi S. Umar,
- Rabi Usman,
- Adamu Atiku,
- Garba Abdullahi,
- Yahaya Buhari,
- Rabiu Sani,
- Husaini U. Bako,
- Bashir Abdullahi,
- Alliyu I. Yarima,
- Badaru Sikiru,
- Aderinola Olaolu Moses,
- Michael O. Popoola,
- Eme Ekeng,
- Adebola Olayinka,
- Nwando Mba,
- Adamu Kankia,
- Ibrahim N. Mamadu,
- Ifeanyi Okudo,
- Mary Stephen,
- Olivier Ronveaux,
- Jason Busuttil,
- Jason M. Mwenda,
- Mohammed Abdulaziz,
- Sulaiman A. Gummi,
- Adebayo Adedeji,
- Andre Bita,
- Linda Omar,
- Mamoudou Harouna Djingarey,
- Wondimagegnehu Alemu,
- Umberto D’Alessandro,
- Chikwe Ihekweazu,
- Martin Antonio
Affiliations
- Brenda A. Kwambana-Adams
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Rahab C. Amaza
- Nigeria Center for Disease Control
- Catherine Okoi
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Murtala Rabiu
- Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State
- Archibald Worwui
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Ebenezer Foster-Nyarko
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Bernard Ebruke
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Abdul K. Sesay
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Madikay Senghore
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Abdullahi S. Umar
- Zamfara State Ministry of Health
- Rabi Usman
- Zamfara State Ministry of Health
- Adamu Atiku
- Zamfara State Ministry of Health
- Garba Abdullahi
- Nigeria Center for Disease Control
- Yahaya Buhari
- Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State
- Rabiu Sani
- Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State
- Husaini U. Bako
- Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State
- Bashir Abdullahi
- Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State
- Alliyu I. Yarima
- Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State
- Badaru Sikiru
- Nigeria Center for Disease Control
- Aderinola Olaolu Moses
- Nigeria Center for Disease Control
- Michael O. Popoola
- Nigeria Center for Disease Control
- Eme Ekeng
- Nigeria Center for Disease Control
- Adebola Olayinka
- Nigeria Center for Disease Control
- Nwando Mba
- Nigeria Center for Disease Control
- Adamu Kankia
- World Health Organization, Country Office Nigeria
- Ibrahim N. Mamadu
- World Health Organization, Country Office Nigeria
- Ifeanyi Okudo
- World Health Organization, Country Office Nigeria
- Mary Stephen
- World Health Organization, Country Office Nigeria
- Olivier Ronveaux
- World Health Organization
- Jason Busuttil
- UK-Public Health Rapid Support Team, Public Health England
- Jason M. Mwenda
- World Health Organization, Regional office for Africa
- Mohammed Abdulaziz
- Africa Centres for Diseases Control and Prevention
- Sulaiman A. Gummi
- Zamfara State Ministry of Health
- Adebayo Adedeji
- Nigeria Center for Disease Control
- Andre Bita
- World Health Organization Inter-Country Support Teams for West Africa
- Linda Omar
- World Health Organization, Regional office for Africa
- Mamoudou Harouna Djingarey
- World Health Organization, Regional office for Africa
- Wondimagegnehu Alemu
- World Health Organization, Country Office Nigeria
- Umberto D’Alessandro
- Disease Control and Elimination Theme, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- Chikwe Ihekweazu
- Nigeria Center for Disease Control
- Martin Antonio
- World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara
- DOI
- https://doi.org/10.1038/s41598-018-32475-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Abstract After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.
Keywords
