Background and Objectives: Love failure can cause intense emotional damage in a person. Therefore, it is necessary to identify and strengthen the factors that improve the experience of an individual with love failure. With this background in mind, the present study aimed to evaluate the effect of spiritual-religious psychotherapy on love trauma syndrome and acceptance of the problem in female students with love failure. Methods: This experimental pretest-posttest study was performed on 30 female undergraduate students with an experience of love failure in Bandar Abbas, Iran, in 2019, using a control group design. The study population was selected through snowball sampling method, and then assigned randomly into two groups of intervention and control. The participants of the intervention group received spiritual-religious psychotherapy, and the final analysis was performed on 27 subjects. Data collection tools entailed Love Trauma Inventory, in addition to Acceptance and Action Questionnaire-II. All data were analyzed by multivariate analysis of variance using SPSS software (version 22). Results: The findings showed that spiritual-religious psychotherapy had a significant effect on love trauma syndrome (F=102.75, P<0.05) and love failure acceptance (F=161.79, P<0.05). Conclusion: According to the results of this study, spiritual-religious psychotherapy can be suggested as an effective approach in improving love trauma syndrome and love failure acceptance in girls. The findings of this study might have various practical implications.