Neuropsychiatric Disease and Treatment (Feb 2024)
Genetic Markers Associated with Postpartum Depression: A Review
Abstract
Joshua Harry Chandra,1,* Candy Kurniawan,1,* Irma Melyani Puspitasari1,2 1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia; 2Center of Excellence for Pharmaceutical Care Innovation, Universitas Padjadjaran, Sumedang, West Java, Indonesia*These authors contributed equally to this workCorrespondence: Irma Melyani Puspitasari, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, West Java, Indonesia, Tel +62 22 84288888 Ext 3510, Email [email protected]: Postpartum depression (PPD) is a common illness in mothers after childbirth. PPD negatively affect the mother’s quality of life and the bond with the infant, which can interfere with the infant’s emotional, social, and cognitive development. PPD is caused by various biological and psychosocial factors. The aim of this review is to summarize the latest evidence of the associations between genetic polymorphisms and PPD. PubMed and Scopus were used as the literature search databases for this review. The keywords used were postpartum depression, postnatal depression, genetic, and polymorphism. Twenty-seven articles were reviewed after screening and applying the inclusion criteria. As results, the serotonin gene ( 5-HTTLPR) and oxytocin genes (OXTR) have the most significant associations with PPD among other genes. Further research on PPD biomarkers should be conducted to diagnose and treat PPD patients.Keywords: postpartum depression, biomarkers, genetic polymorphism, 5-HTTLPR, OXTR
