Sex-dimorphic functions of orexin in neuropsychiatric disorders
Jinghan Zhang,
Kangyu Jin,
Bing Chen,
Shangping Cheng,
Jinfan Jin,
Xiaolan Yang,
Jing Lu,
Qinghai Song
Affiliations
Jinghan Zhang
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China
Kangyu Jin
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, 310003, China
Bing Chen
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, 310003, China
Shangping Cheng
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, 310003, China
Jinfan Jin
Department of Psychiatry, Lishui Second People's Hospital, Lishui, Zhejiang, 323000, China
Xiaolan Yang
Department of Psychiatry, Lishui Second People's Hospital, Lishui, Zhejiang, 323000, China
Jing Lu
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, 310003, China; Corresponding author. Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine; the Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, 310003, China.
Qinghai Song
Department of Psychiatry, Lishui Second People's Hospital, Lishui, Zhejiang, 323000, China; Corresponding author. Department of Psychiatry, Lishui Second People’s Hospital, Lishui, Zhejiang, 323000, China.
The orexin system regulates a variety of physiological functions, including the sleep-wake cycle, addiction, foraging behavior, stress and cognitive functioning. Orexin levels in central and peripheral are related to the pathogenesis of many diseases, most notably the narcolepsy, eating disorders, stress-related psychiatric disorders, and neurodegenerative diseases. Recently, it has been reported that the orexin system is distinctly sexually dimorphic, and is strongly associated with neuropsychiatric disorders. In this review, we analyzed advancements in the sex differences in the orexin system and their connection to psychoneurological conditions. Considering the scarcity of research in this domain, more research is imperative to reveal the underlying mechanisms.
