The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas P. D. Liau; Artem Laktyushin; Isabelle S. Lucet; James M. Murphy; Shenggen Yao; Eden Whitlock; Kimberley Callaghan; Nicos A. Nicola; Nadia J. Kershaw; Jeffrey J. Babon

doi:10.1038/s41467-018-04013-1

Nature Communications (Apr 2018)

The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas P. D. Liau,
Artem Laktyushin,
Isabelle S. Lucet,
James M. Murphy,
Shenggen Yao,
Eden Whitlock,
Kimberley Callaghan,
Nicos A. Nicola,
Nadia J. Kershaw,
Jeffrey J. Babon

Affiliations

Nicholas P. D. Liau: Walter and Eliza Hall Institute, 1G Royal Parade
Artem Laktyushin: Walter and Eliza Hall Institute, 1G Royal Parade
Isabelle S. Lucet: Walter and Eliza Hall Institute, 1G Royal Parade
James M. Murphy: Walter and Eliza Hall Institute, 1G Royal Parade
Shenggen Yao: The University of Melbourne, Royal Parade
Eden Whitlock: Walter and Eliza Hall Institute, 1G Royal Parade
Kimberley Callaghan: Walter and Eliza Hall Institute, 1G Royal Parade
Nicos A. Nicola: Walter and Eliza Hall Institute, 1G Royal Parade
Nadia J. Kershaw: Walter and Eliza Hall Institute, 1G Royal Parade
Jeffrey J. Babon: Walter and Eliza Hall Institute, 1G Royal Parade

DOI: https://doi.org/10.1038/s41467-018-04013-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOCS1.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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