Nature Communications (Nov 2016)
De novo genic mutations among a Chinese autism spectrum disorder cohort
- Tianyun Wang,
- Hui Guo,
- Bo Xiong,
- Holly A.F. Stessman,
- Huidan Wu,
- Bradley P. Coe,
- Tychele N. Turner,
- Yanling Liu,
- Wenjing Zhao,
- Kendra Hoekzema,
- Laura Vives,
- Lu Xia,
- Meina Tang,
- Jianjun Ou,
- Biyuan Chen,
- Yidong Shen,
- Guanglei Xun,
- Min Long,
- Janice Lin,
- Zev N. Kronenberg,
- Yu Peng,
- Ting Bai,
- Honghui Li,
- Xiaoyan Ke,
- Zhengmao Hu,
- Jingping Zhao,
- Xiaobing Zou,
- Kun Xia,
- Evan E. Eichler
Affiliations
- Tianyun Wang
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Hui Guo
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Bo Xiong
- Department of Genome Sciences, University of Washington School of Medicine
- Holly A.F. Stessman
- Department of Genome Sciences, University of Washington School of Medicine
- Huidan Wu
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Bradley P. Coe
- Department of Genome Sciences, University of Washington School of Medicine
- Tychele N. Turner
- Department of Genome Sciences, University of Washington School of Medicine
- Yanling Liu
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Wenjing Zhao
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Kendra Hoekzema
- Department of Genome Sciences, University of Washington School of Medicine
- Laura Vives
- Department of Genome Sciences, University of Washington School of Medicine
- Lu Xia
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Meina Tang
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Jianjun Ou
- Mental Health Institute, the Second Xiangya Hospital, Central South University
- Biyuan Chen
- Children’s Development Behavior Center, Third Affiliated Hospital of Sun Yat-sen University
- Yidong Shen
- Mental Health Institute, the Second Xiangya Hospital, Central South University
- Guanglei Xun
- Mental Health Center of Shandong Province
- Min Long
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Janice Lin
- Department of Genome Sciences, University of Washington School of Medicine
- Zev N. Kronenberg
- Department of Genome Sciences, University of Washington School of Medicine
- Yu Peng
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Ting Bai
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Honghui Li
- Child Healthcare Department, Liuzhou Maternity and Child Healthcare Hospital
- Xiaoyan Ke
- Child Mental Health Research Center, Nanjing Brain Hospital Affiliated of Nanjing Medical University
- Zhengmao Hu
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Jingping Zhao
- Mental Health Institute, the Second Xiangya Hospital, Central South University
- Xiaobing Zou
- Children’s Development Behavior Center, Third Affiliated Hospital of Sun Yat-sen University
- Kun Xia
- The State Key Laboratory of Medical Genetics, School of Life Sciences, Central South University
- Evan E. Eichler
- Department of Genome Sciences, University of Washington School of Medicine
- DOI
- https://doi.org/10.1038/ncomms13316
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Recurrent sporadic mutations are important risk factors for autism spectrum disorders (ASDs) but have been primarily investigated in European cohorts. Here, Eichler, Xia and colleagues analyse risk genes in a large Chinese ASD cohort and find novel recurrences of potential pathogenic significance.
