A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

Bhairab N. Singh; Naoko Koyano-Nakagawa; Wuming Gong; Ivan P. Moskowitz; Cyprian V. Weaver; Elizabeth Braunlin; Satyabrata Das; Jop H. van Berlo; Mary G. Garry; Daniel J. Garry

doi:10.1038/s41467-018-06617-z

Nature Communications (Oct 2018)

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

Bhairab N. Singh,
Naoko Koyano-Nakagawa,
Wuming Gong,
Ivan P. Moskowitz,
Cyprian V. Weaver,
Elizabeth Braunlin,
Satyabrata Das,
Jop H. van Berlo,
Mary G. Garry,
Daniel J. Garry

Affiliations

Bhairab N. Singh: Lillehei Heart Institute, University of Minnesota
Naoko Koyano-Nakagawa: Lillehei Heart Institute, University of Minnesota
Wuming Gong: Lillehei Heart Institute, University of Minnesota
Ivan P. Moskowitz: Departments of Pediatrics, Pathology, and Human Genetics, University of Chicago
Cyprian V. Weaver: Lillehei Heart Institute, University of Minnesota
Elizabeth Braunlin: Lillehei Heart Institute, University of Minnesota
Satyabrata Das: Lillehei Heart Institute, University of Minnesota
Jop H. van Berlo: Lillehei Heart Institute, University of Minnesota
Mary G. Garry: Lillehei Heart Institute, University of Minnesota
Daniel J. Garry: Lillehei Heart Institute, University of Minnesota

DOI: https://doi.org/10.1038/s41467-018-06617-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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