Nature Communications (Oct 2018)

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

  • Bhairab N. Singh,
  • Naoko Koyano-Nakagawa,
  • Wuming Gong,
  • Ivan P. Moskowitz,
  • Cyprian V. Weaver,
  • Elizabeth Braunlin,
  • Satyabrata Das,
  • Jop H. van Berlo,
  • Mary G. Garry,
  • Daniel J. Garry

DOI
https://doi.org/10.1038/s41467-018-06617-z
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 18

Abstract

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Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.