Nature Communications (Oct 2018)
A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
Abstract
Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.