NUPR1 is a critical repressor of ferroptosis

Jiao Liu; Xinxin Song; Feimei Kuang; Qiuhong Zhang; Yangchun Xie; Rui Kang; Guido Kroemer; Daolin Tang

doi:10.1038/s41467-021-20904-2

Nature Communications (Jan 2021)

NUPR1 is a critical repressor of ferroptosis

Jiao Liu,
Xinxin Song,
Feimei Kuang,
Qiuhong Zhang,
Yangchun Xie,
Rui Kang,
Guido Kroemer,
Daolin Tang

Affiliations

Jiao Liu: The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University
Xinxin Song: Department of Surgery, UT Southwestern Medical Center
Feimei Kuang: The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University
Qiuhong Zhang: Department of Surgery, University of Pittsburgh
Yangchun Xie: Department of Oncology, The Second Xiangya Hospital, Central South University
Rui Kang: Department of Surgery, UT Southwestern Medical Center
Guido Kroemer: Université Paris Descartes, Sorbonne Paris Cité
Daolin Tang: The Third Affiliated Hospital, Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University

DOI: https://doi.org/10.1038/s41467-021-20904-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Ferroptosis is an iron-dependent form of oxidative cell death. In this study, the authors show that NUPR1, a stress-inducible transcription factor, may be a driver of ferroptosis resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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