Comparative Analysis of African Swine Fever Virus Genotypes and Serogroups

Abstract

African swine fever virus (ASFV) causes highly lethal hemorrhagic disease among pigs, and ASFV’s extreme antigenic diversity hinders vaccine development. We show that p72 ASFV phylogenetic analysis does not accurately define ASFV hemadsorption inhibition assay serogroups. Thus, conventional ASFV genotyping cannot discriminate between viruses of different virulence or predict efficacy of a specific ASFV vaccine.

Keywords

• African swine fever virus
• genotypes
• phylogenetic analysis
• serogroups
• hemadsorption inhibition assay
• viruses