Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

Lele Song; Renxu Chang; Xia Sun; Liying Lu; Han Gao; Huiying Lu; Ritian Lin; Xiaorong Xu; Zhanju Liu; Lixing Zhan

doi:10.1038/s42003-021-01730-0

Communications Biology (Feb 2021)

Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

Lele Song,
Renxu Chang,
Xia Sun,
Liying Lu,
Han Gao,
Huiying Lu,
Ritian Lin,
Xiaorong Xu,
Zhanju Liu,
Lixing Zhan

Affiliations

Lele Song: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Renxu Chang: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Xia Sun: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Liying Lu: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Han Gao: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Huiying Lu: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Ritian Lin: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Xiaorong Xu: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Zhanju Liu: Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University
Lixing Zhan: CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s42003-021-01730-0
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-induced impairment of intestinal stem cells aggravates intestinal inflammation via miRNA.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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