Nature Communications (May 2021)
Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
- Irma Karabegović,
- Eliana Portilla-Fernandez,
- Yang Li,
- Jiantao Ma,
- Silvana C. E. Maas,
- Daokun Sun,
- Emily A. Hu,
- Brigitte Kühnel,
- Yan Zhang,
- Srikant Ambatipudi,
- Giovanni Fiorito,
- Jian Huang,
- Juan E. Castillo-Fernandez,
- Kerri L. Wiggins,
- Niek de Klein,
- Sara Grioni,
- Brenton R. Swenson,
- Silvia Polidoro,
- Jorien L. Treur,
- Cyrille Cuenin,
- Pei-Chien Tsai,
- Ricardo Costeira,
- Veronique Chajes,
- Kim Braun,
- Niek Verweij,
- Anja Kretschmer,
- Lude Franke,
- Joyce B. J. van Meurs,
- André G. Uitterlinden,
- Robert J. de Knegt,
- M. Arfan Ikram,
- Abbas Dehghan,
- Annette Peters,
- Ben Schöttker,
- Sina A. Gharib,
- Nona Sotoodehnia,
- Jordana T. Bell,
- Paul Elliott,
- Paolo Vineis,
- Caroline Relton,
- Zdenko Herceg,
- Hermann Brenner,
- Melanie Waldenberger,
- Casey M. Rebholz,
- Trudy Voortman,
- Qiuwei Pan,
- Myriam Fornage,
- Daniel Levy,
- Manfred Kayser,
- Mohsen Ghanbari
Affiliations
- Irma Karabegović
- Department of Epidemiology, Erasmus University Medical Center
- Eliana Portilla-Fernandez
- Department of Epidemiology, Erasmus University Medical Center
- Yang Li
- Department of Gastroenterology and Hepatology, Erasmus University Medical Center
- Jiantao Ma
- Friedman School of Nutrition Science and Policy, Tufts University
- Silvana C. E. Maas
- Department of Epidemiology, Erasmus University Medical Center
- Daokun Sun
- Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Emily A. Hu
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Brigitte Kühnel
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Yan Zhang
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Srikant Ambatipudi
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Giovanni Fiorito
- Laboratory of Biostatistics, Department of Biomedical Sciences, University of Sassari
- Jian Huang
- MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s Campus, Imperial College London, Norfolk Place
- Juan E. Castillo-Fernandez
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Kerri L. Wiggins
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU
- Niek de Klein
- Department of Genetics, University Medical Center Groningen, University of Groningen
- Sara Grioni
- Epidemiology and Prevention Unit, IRCCS National Cancer Institute Foundation
- Brenton R. Swenson
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU
- Silvia Polidoro
- MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s Campus, Imperial College London, Norfolk Place
- Jorien L. Treur
- Department of Psychiatry, Amsterdam UMC
- Cyrille Cuenin
- Epigenetics Group, International Agency for Research on Cancer (IARC)
- Pei-Chien Tsai
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Ricardo Costeira
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Veronique Chajes
- Nutritional Epidemiology Group, International Agency for Research on Cancer
- Kim Braun
- Department of Epidemiology, Erasmus University Medical Center
- Niek Verweij
- Department of Genetics, University Medical Center Groningen, University of Groningen
- Anja Kretschmer
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Lude Franke
- Department of Genetics, University Medical Center Groningen, University of Groningen
- Joyce B. J. van Meurs
- Department of Internal Medicine, Erasmus University Medical Center
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus University Medical Center
- Robert J. de Knegt
- Department of Gastroenterology and Hepatology, Erasmus University Medical Center
- M. Arfan Ikram
- Department of Epidemiology, Erasmus University Medical Center
- Abbas Dehghan
- MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s Campus, Imperial College London, Norfolk Place
- Annette Peters
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Ben Schöttker
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Sina A. Gharib
- Computational Medicine Core at Center for Lung Biology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, CHRU
- Jordana T. Bell
- Department of Twin Research and Genetic Epidemiology, Kings College London
- Paul Elliott
- MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s Campus, Imperial College London, Norfolk Place
- Paolo Vineis
- MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, St Mary’s Campus, Imperial College London, Norfolk Place
- Caroline Relton
- MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol
- Zdenko Herceg
- Epigenetics Group, International Agency for Research on Cancer (IARC)
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Melanie Waldenberger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Casey M. Rebholz
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Trudy Voortman
- Department of Epidemiology, Erasmus University Medical Center
- Qiuwei Pan
- Department of Gastroenterology and Hepatology, Erasmus University Medical Center
- Myriam Fornage
- Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Daniel Levy
- Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland and the Framingham Heart Study
- Manfred Kayser
- Department of Genetic Identification, Erasmus University Medical Center
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-22752-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
While coffee and tea consumption has been associated with risk of diseases, their mechanisms of action remain elusive. Here the authors present a large EWAS on coffee and tea consumption in cohorts of European and African-American ancestries, finding that coffee consumption is associated with differential DNA methylation levels at multiple CpGs.
