Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice

Daniel Kroeger; Gianna Absi; Celia Gagliardi; Sathyajit S. Bandaru; Joseph C. Madara; Loris L. Ferrari; Elda Arrigoni; Heike Münzberg; Thomas E. Scammell; Clifford B. Saper; Ramalingam Vetrivelan

doi:10.1038/s41467-018-06590-7

Nature Communications (Oct 2018)

Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice

Daniel Kroeger,
Gianna Absi,
Celia Gagliardi,
Sathyajit S. Bandaru,
Joseph C. Madara,
Loris L. Ferrari,
Elda Arrigoni,
Heike Münzberg,
Thomas E. Scammell,
Clifford B. Saper,
Ramalingam Vetrivelan

Affiliations

Daniel Kroeger: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Gianna Absi: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Celia Gagliardi: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Sathyajit S. Bandaru: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Joseph C. Madara: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School
Loris L. Ferrari: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Elda Arrigoni: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Heike Münzberg: Neurobiology of Nutrition and Metabolism, Pennington Biomedical Research Center, Louisiana State University System
Thomas E. Scammell: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Clifford B. Saper: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School
Ramalingam Vetrivelan: Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-06590-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Anatomical lesions of the preoptic area (POA) can cause sleep loss while electrical, chemical, or thermal stimulation of POA can induce sleep. To better understand the exact neural function of the POA, this study shows that galanin and GABA+ inhibitory neurons in the ventrolateral POA that project to the wake-promoting tuberomammillary nucleus promote sleep in a stimulation frequency dependent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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