Animal Models for Parkinson’s Disease Research: Trends in the 2000s

Abstract

Parkinson’s disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.

Keywords

• animal model
• α-synuclein
• dj-1
• neurotoxin
• parkin
• parkinson’s disease
• pesticide
• pink1
• 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
• 6-hydroxydopamine