Access to Axially Chiral Aryl Aldehydes via Carbene-Catalyzed Nitrile Formation and Desymmetrization Reaction
Yuanlin Cai,
Ya Lv,
Liangzhen Shu,
Zhichao Jin,
Yonggui Robin Chi,
Tingting Li
Affiliations
Yuanlin Cai
National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education,
Guizhou University, Guiyang 550025, China.
Ya Lv
National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education,
Guizhou University, Guiyang 550025, China.
Liangzhen Shu
National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education,
Guizhou University, Guiyang 550025, China.
Zhichao Jin
National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education,
Guizhou University, Guiyang 550025, China.
Yonggui Robin Chi
National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education,
Guizhou University, Guiyang 550025, China.
Tingting Li
National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education,
Guizhou University, Guiyang 550025, China.
An approach utilizing N-heterocyclic carbene for nitrile formation and desymmetrization reaction is developed. The process involves kinetic resolution, with the axially chiral aryl monoaldehydes obtained in moderate yields with excellent optical purities. These axially chiral aryl monoaldehydes can be conveniently transformed into functionalized molecules, showing great potential as catalysts in organic chemistry.
