Molecular characterization of Panton-Valentine leukocidin (PVL) toxin–encoding phages from South India

V. Balaji; D.B. Yamuna; Y.I. Francis; G. Priya Doss

doi:10.1016/j.nmni.2017.08.005

New Microbes and New Infections (Nov 2017)

Molecular characterization of Panton-Valentine leukocidin (PVL) toxin–encoding phages from South India

V. Balaji,
D.B. Yamuna,
Y.I. Francis,
G. Priya Doss

Affiliations

V. Balaji: Department of Clinical Microbiology, Christian Medical College, Vellore, India
D.B. Yamuna: Department of Clinical Microbiology, Christian Medical College, Vellore, India
Y.I. Francis: Department of Clinical Microbiology, Christian Medical College, Vellore, India
G. Priya Doss: Department of Integrative Biology, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India

DOI: https://doi.org/10.1016/j.nmni.2017.08.005
Journal volume & issue: Vol. 20, no. C
pp. 34 – 38

Abstract

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A total of 19 methicillin-resistant Staphylococcus aureus (MRSA) isolates were investigated for Panton-Valentine leukocidin (PVL) toxin, PVL gene sequence variation and PVL-encoding phages. Whole genome sequencing was performed for all isolates. Analysis of MRSA isolates (n = 19) confirmed that most MRSA (n = 11) were positive for the PVL gene and were multidrug resistant. ST772-MRSA-V was the predominant PVL-positive MRSA clone, although all of them were found to carry the ΦIND772PVL phage in the genome. This study provides insights into the evolution of a new lineage of PVL-MRSA and highlights the potential risk of the emergence of multidrug-resistant community-acquired MRSA with high virulence.

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.sciencedirect.com/journal/new-microbes-and-new-infections

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