The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria

Amaia González-Magaña; Jon Altuna; María Queralt-Martín; Eneko Largo; Carmen Velázquez; Itxaso Montánchez; Patricia Bernal; Antonio Alcaraz; David Albesa-Jové

doi:10.1038/s42003-022-04140-y

Communications Biology (Nov 2022)

The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria

Amaia González-Magaña,
Jon Altuna,
María Queralt-Martín,
Eneko Largo,
Carmen Velázquez,
Itxaso Montánchez,
Patricia Bernal,
Antonio Alcaraz,
David Albesa-Jové

Affiliations

Amaia González-Magaña: Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, Instituto Biofisika (CSIC, UPV/EHU), University of the Basque Country
Jon Altuna: Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, Instituto Biofisika (CSIC, UPV/EHU), University of the Basque Country
María Queralt-Martín: Laboratory of Molecular Biophysics, Department of Physics, University Jaume I
Eneko Largo: Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, Instituto Biofisika (CSIC, UPV/EHU), University of the Basque Country
Carmen Velázquez: Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, Instituto Biofisika (CSIC, UPV/EHU), University of the Basque Country
Itxaso Montánchez: Departamento de Inmunología, Microbiología y Parasitología, University of the Basque Country
Patricia Bernal: Departamento de Microbiología, Facultad de Biología, Universidad de Sevilla
Antonio Alcaraz: Laboratory of Molecular Biophysics, Department of Physics, University Jaume I
David Albesa-Jové: Fundación Biofísica Bizkaia/Biofisika Bizkaia Fundazioa (FBB) and Departamento de Bioquímica y Biología Molecular, Instituto Biofisika (CSIC, UPV/EHU), University of the Basque Country

DOI: https://doi.org/10.1038/s42003-022-04140-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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The Pseudomonas aeruginosa Type 6 secretion effector Tse5 forms pores in the cytoplasmic membrane when ectopically produced and hence has a bacteriolytic effect by depolarising the inner membrane potential.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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