Nature Communications (Jan 2020)
White blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer
- Alessandro Leal,
- Nicole C. T. van Grieken,
- Doreen N. Palsgrove,
- Jillian Phallen,
- Jamie E. Medina,
- Carolyn Hruban,
- Mark A. M. Broeckaert,
- Valsamo Anagnostou,
- Vilmos Adleff,
- Daniel C. Bruhm,
- Jenna V. Canzoniero,
- Jacob Fiksel,
- Marianne Nordsmark,
- Fabienne A. R. M. Warmerdam,
- Henk M. W. Verheul,
- Dick Johan van Spronsen,
- Laurens V. Beerepoot,
- Maud M. Geenen,
- Johanneke E. A. Portielje,
- Edwin P. M. Jansen,
- Johanna van Sandick,
- Elma Meershoek-Klein Kranenbarg,
- Hanneke W. M. van Laarhoven,
- Donald L. van der Peet,
- Cornelis J. H. van de Velde,
- Marcel Verheij,
- Remond Fijneman,
- Robert B. Scharpf,
- Gerrit A. Meijer,
- Annemieke Cats,
- Victor E. Velculescu
Affiliations
- Alessandro Leal
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Nicole C. T. van Grieken
- Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit
- Doreen N. Palsgrove
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jillian Phallen
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jamie E. Medina
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Carolyn Hruban
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Mark A. M. Broeckaert
- Department of Pathology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit
- Valsamo Anagnostou
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Vilmos Adleff
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Daniel C. Bruhm
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Jenna V. Canzoniero
- Department of Medicine, Johns Hopkins University School of Medicine
- Jacob Fiksel
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Marianne Nordsmark
- Department of Oncology, Aarhus University Hospital
- Fabienne A. R. M. Warmerdam
- Department of Medical Oncology, Zuyderland Medical Centre
- Henk M. W. Verheul
- Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit
- Dick Johan van Spronsen
- Department of Hematology, Radboud University Nijmegen Medical Centre
- Laurens V. Beerepoot
- Department of Internal Medicine, St. Elisabeth-Tweesteden Ziekenhuis
- Maud M. Geenen
- Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis
- Johanneke E. A. Portielje
- Department of Internal Medicine, HAGA hospital
- Edwin P. M. Jansen
- Department of Radiation Oncology, Netherlands Cancer Institute
- Johanna van Sandick
- Department of Surgery, Netherlands Cancer Institute
- Elma Meershoek-Klein Kranenbarg
- Department of Surgery, Leiden University Medical Center
- Hanneke W. M. van Laarhoven
- Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC
- Donald L. van der Peet
- Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit
- Cornelis J. H. van de Velde
- Department of Surgery, Leiden University Medical Center
- Marcel Verheij
- Department of Radiation Oncology, Netherlands Cancer Institute
- Remond Fijneman
- Department of Pathology, Diagnostic Oncology, Netherlands Cancer Institute
- Robert B. Scharpf
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- Gerrit A. Meijer
- Department of Pathology, Diagnostic Oncology, Netherlands Cancer Institute
- Annemieke Cats
- Department of Gastrointestinal Oncology, Netherlands Cancer Institute
- Victor E. Velculescu
- The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-14310-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Identifying patients that will respond to a particular therapy remains a key challenge in precision oncology. Here, in gastric cancer, the authors show that circulating tumour DNA can predict recurrence, provided that the signal from white blood cells is filtered out.
