Aminothiolation of alkenes with azoles and Bunte salts

Bingqing Ouyang; Xing Chai; Zhe Li; Chunling Zhang; Xingmei Liu

doi:10.3389/fchem.2023.1328441

Frontiers in Chemistry (Jan 2024)

Aminothiolation of alkenes with azoles and Bunte salts

Bingqing Ouyang,
Xing Chai,
Zhe Li,
Chunling Zhang,
Xingmei Liu

Affiliations

Bingqing Ouyang: Department of Pharmacy, The Second Norman Bethune Hospital of Jilin University, Changchun, China
Xing Chai: Outpatient Department, The Second Norman Bethune Hospital of Jilin University, Changchun, China
Zhe Li: Department of Pharmacy, The Second Norman Bethune Hospital of Jilin University, Changchun, China
Chunling Zhang: Department of Pharmacy, The Second Norman Bethune Hospital of Jilin University, Changchun, China
Xingmei Liu: Department of Pharmacy, The Second Norman Bethune Hospital of Jilin University, Changchun, China

DOI: https://doi.org/10.3389/fchem.2023.1328441
Journal volume & issue: Vol. 11

Abstract

Read online

We have developed an intermolecular aminothiolation of simple olefins using Bunte salt as a thiolating agent. This protocol produces thiyl free radicals under PIDA oxidation conditions, eliminating the need for transition-metal catalysts. The method has a wide range of substrate applicability and is suitable for large-scale preparation and late-stage modification of drug molecules.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

About the journal

Abstract

Keywords