Journal of Veterinary Research (Jan 2020)

Potential role of macrophage migration inhibitory factor in the pathogenesis of Marek’s disease

  • Fan Zhongjun,
  • Wang Huanli,
  • Pan Jiahao,
  • Yu Shupei,
  • Xia Wenlong

DOI
https://doi.org/10.2478/jvetres-2020-0009
Journal volume & issue
Vol. 64, no. 1
pp. 33 – 38

Abstract

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Marek’s disease virus (MDV) can cause malignant T-cell lymphomas and immunosuppression in chickens. Macrophage migration inhibitory factor (MIF) not only plays a critical role in inhibiting T-cell responses, but also contributes to multiple aspects of tumour progression. The aim of this study was to reveal the potential role of MIF in the pathogenesis of MDV infection.

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