The Role of Paternal History of Type 2 Diabetes Mellitus on Prediabetes Status among The Offspring of Type 2 Diabetes Mellitus Patients

Abstract

Introduction. Since patients with type 2 diabetes mellitus (T2DM) often present with one or more chronic complications, at the time of diagnosis, early detection and prevention is essential to reduce T2DM-associated mortality and morbidity, espescially among high risk population such as the offspring of T2DM. This study aimed to investigate several factors associated with prediabetes status among the offsprings of T2DM patients. Methods. A cross-sectional study was conducted involving 54 offsprings of T2DM patients. Subjects were recruited consecutively. We collected demographic data, anthropometric measurement, blood pressure, and HbA1c level. Physical activity were assessed by using Indonesian version of global physical activity questionnaire (GPAQ). Prediabetes status was investigated by standardized national glycohemoglobin standardization program (NGSP) HbA1c. Bivariate statistical and multivariate analysis was performed by using IBM SPSS 23. Results: The majority of subjects were female (79.6%) and the mean age was 38.8 years old. The proportion of prediabetes was 31.5%. Multivariate analysis showed significant association among paternal history of T2DM (adjusted OR 7.520; 95%CI=1.071-52.784), waist circumference at risk (adjusted OR 5.482; 95%CI=1.019-29.504), and prediabetes status. Conclusion: Paternal history of T2DM and waist circumference were associated with prediabetes status among the offspring of T2DM patients.

Keywords

• glycated hemoglobin
• glucose intolerance
• offspring of t2dm
• prediabetes
• type 2 diabetes mellitus (t2dm)