Zhongguo quanke yixue (Jun 2023)

Association between Air Pollutant Exposure and Dyslipidemia in Middle-aged and Elderly People in Mining Areas

  • FENG Shuidong, LI Junyan, DENG Shuxiang, CHEN Limou, CAO Mengyue, TANG Yan, TANG Peng, LIU Jun, SHEN Minxue, YANG Fei

DOI
https://doi.org/10.12114/j.issn.1007-9572.2022.0809
Journal volume & issue
Vol. 26, no. 18
pp. 2238 – 2244

Abstract

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Background Dyslipidemia has become one of the global public health issues. However, the relationship between air pollution and dyslipidemia has been rarely reported. Objective To explore the relationship between air pollutant exposure and dyslipidemia in middle-aged and elderly people in mining areas. Methods A total of 1 965 residents over 45 years old were sampled using cluster random sampling from mining areas in western Hunan from 2018 to 2019. The general data and lipid indices were obtained by using an interviewer-administered questionnaire survey, a physical examination and a laboratory test. The level of air pollution of the mining area was calculated by inverse distance weighted interpolation, and the average daily dose (ADDtotal) of air pollutants of each resident was calculated, and used to divide them into Q1 group (0.5-0.7 m3·kg-1·d-1, n=172), Q2 group (>0.7-0.9 m3·kg-1·d-1, n=870), Q3 group (>0.9-1.1 m3·kg-1·d-1, n=717), and Q4 group (>1.1 m3·kg-1·d-1, n=172). Unconditional Logistic regression was used to analyze the relationship between ADDtotal and dyslipidemia. Results The annual average concentration of PM2.5 in the two mining areas exceeded the National Air Quality Standard (Ⅱ). The prevalence rate of dyslipidemia was 25.3% (498/1 965). There were statistically significant differences in mean age and body mass index (BMI), prevalence of smoking and hypertension between patients with normal and dyslipidemia (P<0.05). The detection ratios of abnormal triglyceride (TG) and high density lipoprotein cholesterol in Q1 to Q4 groups were statistically significant different (P<0.05). After adjusting for age, sex, hypertension, BMI, smoking, diabetes, drinking and other factors, unconditional Logistic regression analysis found that Q2, Q3 and Q4 groups had a greater risk of abnormal TG (P<0.05), and Q4 group also had a greater risk of abnormal total cholesterol (TC) (P<0.05), compared with group Q1 (with the lowest concentration of ADDtotal) . Conclusion The air pollutants in the two mining areas were mainly PM2.5, the ADDtotal of air pollutants was positively correlated with TC and TG anomalies, which provides a reference for further research on the relationship between air pollutant exposure and dyslipidemia.

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