Central giant cell granuloma: A report of 2 cases and review of literature

Abstract

Central giant cell granuloma (CGCG) is a non-neoplastic lesion which exhibits a spectrum of clinical behavior ranging from non-aggressive to aggressive variants. The etiopathogenesis of CGCG is still not properly known. In the maxillofacial region, CGCG most commonly occurs in the jaw bones as an asymptomatic swelling. Radiographically, it presents as either unilocular or multilocular radiolucent lesions in the maxilla or mandible. Treatment of CGCG varies from local curettage to wide surgical excision depending upon the extent and progression of the lesion. This paper presents two cases of CGCG having different clinical presentation which resembled varied conditions leading to misdiagnosis (in one case), but was found to be CGCG on histopathologic examination.

Keywords

• Giant cell granuloma
• immunohistochemical staining
• mandible
• multinucleated giant cells
• non-neoplastic lesion