Novel insights into biomarkers of progression in Desmoid tumor

Baiqi Liu; Baiqi Liu; Zefang Sun; Zefang Sun; Rui Zhou; Dingcheng Shen; Dingcheng Shen; Shuai Zhu; Shuai Zhu; Lu Chen; Lu Chen; Gengwen Huang; Gengwen Huang

doi:10.3389/fonc.2023.1206800

Frontiers in Oncology (Aug 2023)

Novel insights into biomarkers of progression in Desmoid tumor

Baiqi Liu,
Baiqi Liu,
Zefang Sun,
Zefang Sun,
Rui Zhou,
Dingcheng Shen,
Dingcheng Shen,
Shuai Zhu,
Shuai Zhu,
Lu Chen,
Lu Chen,
Gengwen Huang,
Gengwen Huang

Affiliations

Baiqi Liu: Department of Hernia and Abdominal Wall Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China
Baiqi Liu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Zefang Sun: Department of Hernia and Abdominal Wall Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China
Zefang Sun: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Rui Zhou: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Dingcheng Shen: Department of Hernia and Abdominal Wall Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China
Dingcheng Shen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Shuai Zhu: Department of Hernia and Abdominal Wall Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China
Shuai Zhu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Lu Chen: Department of Hernia and Abdominal Wall Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China
Lu Chen: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Gengwen Huang: Department of Hernia and Abdominal Wall Surgery, General Surgery, Xiangya Hospital, Central South University, Changsha, China
Gengwen Huang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China

DOI: https://doi.org/10.3389/fonc.2023.1206800
Journal volume & issue: Vol. 13

Abstract

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Desmoid tumor (DT) is a rare neoplasm characterized by the proliferation of myofibroblastic cells that infiltrates and invades adjacent tissues. Due to its locally aggressive and recurrent nature, DT often causes local symptoms and can be challenging to manage clinically. Therefore, identifying biomarkers that can predict the progression of DT and guide treatment decisions is critical. This review summarizes several biomarkers that have been implicated in active surveillance (AS) and the prediction of postoperative recurrence and attempts to elucidate their underlying mechanisms. Some of these novel markers could provide prognostic value for clinicians, and ultimately help facilitate optimal and accurate therapeutic decisions for DT.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

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