Nature Communications (Jun 2017)

Hypoxia-induced mobilization of NHE6 to the plasma membrane triggers endosome hyperacidification and chemoresistance

  • Fabrice Lucien,
  • Pierre-Paul Pelletier,
  • Roxane R. Lavoie,
  • Jean-Michel Lacroix,
  • Sébastien Roy,
  • Jean-Luc Parent,
  • Dominique Arsenault,
  • Kelly Harper,
  • Claire M. Dubois

DOI
https://doi.org/10.1038/ncomms15884
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Sodium/proton exchangers (NHEs) are critical regulators of pH within the cell and the extracellular microenvironment. Here, the authors show that hypoxia induces mobilization of NHE6 from endosomal compartment to the plasma membrane in a PKC-dependent manner inducing hyper acidification of endosomes and drug resistance.