Journal of Pediatric Surgery Case Reports (Mar 2021)
Multi-disciplinary treatment of undifferentiated embryonal sarcoma of the liver with tumor embolus extending to the heart
- Kunio Fukuda,
- Ai Yoshimi,
- Miki Toma,
- Satoru Matsushima,
- Norihiko Kitagawa,
- Masato Shinkai,
- Noritaka Ota,
- Toshihide Asou,
- Mio Tanaka,
- Yukichi Tanaka,
- Chie Kobayashi,
- Takayuki Masuko,
- Asai Nobuyoshi,
- Keisuke Kato,
- Junko Shiono,
- Haruo Ohtani,
- Kazutoshi Koike,
- Tatsuo Kono,
- Toshihiro Yanai,
- Masahiro Tsuchida
Affiliations
- Kunio Fukuda
- Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan
- Ai Yoshimi
- Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan; Divisions of Institute of Pediatric Medicine and Cancer Research, Ibaraki Children's Hospital, Mito, Japan
- Miki Toma
- Divisions of Pediatric Surgery, Ibaraki Children's Hospital, Mito, Japan
- Satoru Matsushima
- Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan
- Norihiko Kitagawa
- Divisions of Pediatric Surgery, Kanagawa Children's Medical Center, Yokohama, Japan
- Masato Shinkai
- Divisions of Pediatric Surgery, Kanagawa Children's Medical Center, Yokohama, Japan
- Noritaka Ota
- Divisions of Cardiovascular Surgery, Kanagawa Children's Medical Center, Yokohama, Japan; Division of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
- Toshihide Asou
- Divisions of Cardiovascular Surgery, Kanagawa Children's Medical Center, Yokohama, Japan
- Mio Tanaka
- Divisions of Pediatric Pathology, Kanagawa Children's Medical Center, Yokohama, Japan
- Yukichi Tanaka
- Divisions of Pediatric Pathology, Kanagawa Children's Medical Center, Yokohama, Japan
- Chie Kobayashi
- Divisions of General Pediatrics, Ibaraki Children's Hospital, Mito, Japan
- Takayuki Masuko
- Divisions of Pediatric Surgery, Ibaraki Children's Hospital, Mito, Japan
- Asai Nobuyoshi
- Divisions of Clinical Laboratory, Ibaraki Children's Hospital, Mito, Japan
- Keisuke Kato
- Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan; Divisions of Institute of Pediatric Medicine and Cancer Research, Ibaraki Children's Hospital, Mito, Japan; Corresponding author. Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.
- Junko Shiono
- Divisions of Pediatric Cardiology, Ibaraki Children's Hospital, Mito, Japan
- Haruo Ohtani
- Divisions of Pediatric Pathology, Ibaraki Children's Hospital, Mito, Japan
- Kazutoshi Koike
- Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan; Divisions of Institute of Pediatric Medicine and Cancer Research, Ibaraki Children's Hospital, Mito, Japan
- Tatsuo Kono
- Division of Clinical Radiology, Tokyo Metropolitan Children's Medical Center, Fuchu, Tokyo, Japan
- Toshihiro Yanai
- Divisions of Pediatric Surgery, Ibaraki Children's Hospital, Mito, Japan
- Masahiro Tsuchida
- Divisions of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan
- Journal volume & issue
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Vol. 66
p. 101705
Abstract
Undifferentiated embryonal sarcoma of the liver (UESL) is a highly malignant neoplasm occurring predominantly in children. Complete resection is the only curative treatment. We encountered an 11-year-old boy with UESL arising in the right lobe of the liver extending to the pulmonary valve. He was treated with IREC (irinotecan, etoposide, and carboplatin) neoadjuvant chemotherapy, concurrent extended radical right hepatectomy, and intracardiac tumorectomy under cardiopulmonary bypass, and adjuvant IREC chemotherapy. He remains in remission without complications 48 months after diagnosis. Multidisciplinary treatment, particularly the combination of radical surgery and effective neoadjuvant chemotherapy, may contribute to UESL patients' survival.
