The Impact of Capecitabine and Combined Training on BRCA1 Gene Expression in Breast Cancer Induction

Abstract

Introduction: This study explores the combined effects of concurrent training and capecitabine consumption on breast cancer prevention and therapy, focusing on the modulation of BRCA1 gene expression. Material & Methods: In the main study, 12 mice were divided into groups, including Exercise-Tumor-Exercise (ETE), Exercise-Tumor-Exercise+Drug (ETE + D), and various others. Resistance and endurance training were conducted five days a week for 12 weeks before and eight weeks after tumor induction, accompanied by capecitabine administration. BRCA1 gene expression was assessed post-intervention using SPSS 20. Results: MC4-L2 injection induced tumors. Both pre and post-cancer induction, exercise significantly increased BRCA1 gene expression (p = 0.001, p = 0.001). Exercise combined with post-cancer capecitabine led to increased BRCA1 expression (p = 0.001). Capecitabine alone post-cancer also elevated BRCA1 expression (p = 0.001). Exercise, exercise with capecitabine, and capecitabine alone post-cancer showed significantly higher BRCA1 expression than exercise pre-cancer (p = 0.001). Exercise-tumor-exercise and Exercise-Tumor-Exercise+Drug groups exhibited increased BRCA1 expression compared to exercise-tumor-drug (p = 0.001). Conclusion: The ETE+D protocol, involving exercise and capecitabine post-cancer, increased BRCA1 expression, suggesting potential roles in tumor prevention and therapy.

Keywords

• breast cancer
• tumor size
• exercise therapy
• brca1
• capecitabine