Nature Communications (Dec 2020)
Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
- Enrico Girardi,
- Gennaro Agrimi,
- Ulrich Goldmann,
- Giuseppe Fiume,
- Sabrina Lindinger,
- Vitaly Sedlyarov,
- Ismet Srndic,
- Bettina Gürtl,
- Benedikt Agerer,
- Felix Kartnig,
- Pasquale Scarcia,
- Maria Antonietta Di Noia,
- Eva Liñeiro,
- Manuele Rebsamen,
- Tabea Wiedmer,
- Andreas Bergthaler,
- Luigi Palmieri,
- Giulio Superti-Furga
Affiliations
- Enrico Girardi
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Gennaro Agrimi
- Laboratory of Biochemistry and Molecular Biology, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari
- Ulrich Goldmann
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Giuseppe Fiume
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Sabrina Lindinger
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Vitaly Sedlyarov
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Ismet Srndic
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Bettina Gürtl
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Benedikt Agerer
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Felix Kartnig
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Pasquale Scarcia
- Laboratory of Biochemistry and Molecular Biology, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari
- Maria Antonietta Di Noia
- Laboratory of Biochemistry and Molecular Biology, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari
- Eva Liñeiro
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Manuele Rebsamen
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Tabea Wiedmer
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Andreas Bergthaler
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Luigi Palmieri
- Laboratory of Biochemistry and Molecular Biology, Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari
- Giulio Superti-Furga
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-020-19871-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Maintenance of a mitochondrial NAD+ pool is critical for cellular life, yet the existence and identity of the transporter responsible for mitochondrial NAD+ uptake was unknown until recently. Here, the authors use genomic, genetic, and metabolomic approaches to demonstrate that SLC25A51 controls NAD+ mitochondrial levels and is the functional homolog of the yeast mitochondrial NAD+ transporter.
