Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART Era

Rosiris León-Rivera; Mike Veenstra; Maribel Donoso; Elizabeth Tell; Eliseo A. Eugenin; Susan Morgello; Joan W. Berman

doi:10.1128/mBio.03633-20

mBio (Apr 2021)

Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART Era

Rosiris León-Rivera,
Mike Veenstra,
Maribel Donoso,
Elizabeth Tell,
Eliseo A. Eugenin,
Susan Morgello,
Joan W. Berman

Affiliations

Rosiris León-Rivera: ORCiD; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
Mike Veenstra: Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
Maribel Donoso: Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas, USA
Elizabeth Tell: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Eliseo A. Eugenin: ORCiD; Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas, USA
Susan Morgello: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Joan W. Berman: ORCiD; Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA

DOI: https://doi.org/10.1128/mBio.03633-20
Journal volume & issue: Vol. 12, no. 2

Abstract

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We characterized mechanisms of CNS viral reservoir establishment/replenishment using peripheral blood mononuclear cells (PBMC) of PLWH on cART and propose therapeutic targets to reduce/block selective entry of cells harboring HIV (HIV +++

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal