mBio
(Apr 2021)
Central Nervous System (CNS) Viral Seeding by Mature Monocytes and Potential Therapies To Reduce CNS Viral Reservoirs in the cART Era
Rosiris León-Rivera,
Mike Veenstra,
Maribel Donoso,
Elizabeth Tell,
Eliseo A. Eugenin,
Susan Morgello,
Joan W. Berman
Affiliations
Rosiris León-Rivera
ORCiD Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
Mike Veenstra
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
Maribel Donoso
Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas, USA
Elizabeth Tell
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Eliseo A. Eugenin
ORCiD Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, Texas, USA
Susan Morgello
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
Joan W. Berman
ORCiD Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
DOI
https://doi.org/10.1128/mBio.03633-20
Journal volume & issue
Vol. 12,
no. 2
Abstract
Read online
We characterized mechanisms of CNS viral reservoir establishment/replenishment using peripheral blood mononuclear cells (PBMC) of PLWH on cART and propose therapeutic targets to reduce/block selective entry of cells harboring HIV (HIV +++
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