Pd/C-Mediated synthesis of indoles in water

Abstract

We describe the utility of a Pd/C-Cu mediated method in the synthesis of 2,5-disubstituted indoles in water via a coupling-cyclization strategy. Further application of this methodology has been demonstrated in the preparation of a target indole derivative via a 7-step process the key step being the Pd/C-mediated coupling reaction.

Keywords

• C–C bond
• charcoal
• copper
• indoles
• palladium