mBio (Feb 2021)
Hyaluronidase Impairs Neutrophil Function and Promotes Group B <i>Streptococcus</i> Invasion and Preterm Labor in Nonhuman Primates
- Michelle Coleman,
- Blair Armistead,
- Austyn Orvis,
- Phoenicia Quach,
- Alyssa Brokaw,
- Claire Gendrin,
- Kavita Sharma,
- Jason Ogle,
- Sean Merillat,
- Matthew Dacanay,
- Tsung-Yen Wu,
- Jeff Munson,
- Audrey Baldessari,
- Jay Vornhagen,
- Anna Furuta,
- Shayla Nguyen,
- Kristina M. Adams Waldorf,
- Lakshmi Rajagopal
Affiliations
- Michelle Coleman
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Blair Armistead
- ORCiD
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Austyn Orvis
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Phoenicia Quach
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Alyssa Brokaw
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Claire Gendrin
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Kavita Sharma
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Jason Ogle
- Washington National Primate Research Center, Seattle, Washington, USA
- Sean Merillat
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Matthew Dacanay
- Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington, USA
- Tsung-Yen Wu
- Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, Washington, USA
- Jeff Munson
- Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
- Audrey Baldessari
- Washington National Primate Research Center, Seattle, Washington, USA
- Jay Vornhagen
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Anna Furuta
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Shayla Nguyen
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- Kristina M. Adams Waldorf
- ORCiD
- Department of Global Health, University of Washington, Seattle, Washington, USA
- Lakshmi Rajagopal
- ORCiD
- Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA
- DOI
- https://doi.org/10.1128/mBio.03115-20
- Journal volume & issue
-
Vol. 12,
no. 1
Abstract
Group B streptococci (GBS) are bacteria that commonly reside in the female lower genital tract as asymptomatic members of the microbiota. However, during pregnancy, GBS can infect tissues at the maternal-fetal interface, leading to preterm birth, stillbirth, or fetal injury.
