Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study
Giacomo Farì,
Marisa Megna,
Salvatore Scacco,
Maurizio Ranieri,
Maria Vittoria Raele,
Enrica Chiaia Noya,
Dario Macchiarola,
Francesco Paolo Bianchi,
Davide Carati,
Simona Panico,
Eleonora Di Campi,
Antonio Gnoni,
Venera Scacco,
Alessio Danilo Inchingolo,
Erda Qorri,
Antonio Scarano,
Biagio Rapone
Affiliations
Giacomo Farì
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Marisa Megna
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Salvatore Scacco
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Maurizio Ranieri
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Maria Vittoria Raele
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Enrica Chiaia Noya
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Dario Macchiarola
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Francesco Paolo Bianchi
Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, 70121 Bari, Italy
Davide Carati
Ansce Bio Generic, 73020 Carpignano Salentinono, Italy
Simona Panico
Ansce Bio Generic, 73020 Carpignano Salentinono, Italy
Eleonora Di Campi
Ansce Bio Generic, 73020 Carpignano Salentinono, Italy
Antonio Gnoni
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Venera Scacco
Department of Translational Biomedicine and Neuroscience (DiBraiN), Aldo Moro University, 70121 Bari, Italy
Alessio Danilo Inchingolo
Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
Erda Qorri
Dean Faculty of Medical Sciences, Albanian University, 1001 Tirana, Albania
Antonio Scarano
Department of Oral Science, Nano and Biotechnology, CaSt-Met University of Chieti-Pescara, 66100 Chieti, Italy
Biagio Rapone
Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70121 Bari, Italy
Background and Objectives: Nutraceuticals are gaining more and more importance as a knee osteoarthritis (KOA) complementary treatment. Among nutraceuticals, hemp seed oil and terpenes are proving to be very useful as therapeutic support for many chronic diseases, but there are still few studies regarding their effectiveness for treating KOA, both in combination and separately. The aim of this study is thus to compare the effect of two dietary supplements, both containing hemp seed oil, but of which only one also contains terpenes, in relieving pain and improving joint function in patients suffering from KOA. Materials and Methods: Thirty-eight patients were recruited and divided into two groups. The control group underwent a 45 day treatment with a hemp seed oil-based dietary supplement, while the treatment group assumed a hemp seed oil and terpenes dietary supplement for the same period. Patients were evaluated at the enrollment (T0) and at the end of treatment (T1). Outcome measures were: Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), Short-Form-12 (SF-12), Knee Injury Osteoarthritis Outcome Score (KOOS), and Oxford Knee Score (OKS). Results: All outcome measures improved at T1 in both groups, but NRS, KOOS and OKS had a greater significant improvement in the treatment group only. Conclusions: Hemp seed oil and terpenes resulted a more effective integrative treatment option in KOA, improving joint pain and function and representing a good complementary option for patients suffering from osteoarthritis.
