Nature Communications (Feb 2019)
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
- Ilias Angelidis,
- Lukas M. Simon,
- Isis E. Fernandez,
- Maximilian Strunz,
- Christoph H. Mayr,
- Flavia R. Greiffo,
- George Tsitsiridis,
- Meshal Ansari,
- Elisabeth Graf,
- Tim-Matthias Strom,
- Monica Nagendran,
- Tushar Desai,
- Oliver Eickelberg,
- Matthias Mann,
- Fabian J. Theis,
- Herbert B. Schiller
Affiliations
- Ilias Angelidis
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- Lukas M. Simon
- Helmholtz Zentrum München, Institute of Computational Biology
- Isis E. Fernandez
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- Maximilian Strunz
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- Christoph H. Mayr
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- Flavia R. Greiffo
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- George Tsitsiridis
- Helmholtz Zentrum München, Institute of Computational Biology
- Meshal Ansari
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- Elisabeth Graf
- Helmholtz Zentrum München, Institute of Human Genetics
- Tim-Matthias Strom
- Helmholtz Zentrum München, Institute of Human Genetics
- Monica Nagendran
- Department of Internal Medicine, Division of Pulmonary and Critical Care, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Tushar Desai
- Department of Internal Medicine, Division of Pulmonary and Critical Care, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
- Oliver Eickelberg
- Department of Medicine, Division of Respiratory Sciences and Critical Care Medicine, University of Colorado
- Matthias Mann
- Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry
- Fabian J. Theis
- Helmholtz Zentrum München, Institute of Computational Biology
- Herbert B. Schiller
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Member of the German Center for Lung Research (DZL)
- DOI
- https://doi.org/10.1038/s41467-019-08831-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Aging impacts lung functionality and makes it more susceptible to chronic diseases. Combining proteomics and single cell transcriptomics, the authors chart molecular and cellular changes in the aging mouse lung, discover aging hallmarks, and predict the cellular sources of regulated proteins.
