Nature Communications (Jul 2020)

Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

  • Chun Su,
  • Matthew E. Johnson,
  • Annabel Torres,
  • Rajan M. Thomas,
  • Elisabetta Manduchi,
  • Prabhat Sharma,
  • Parul Mehra,
  • Carole Le Coz,
  • Michelle E. Leonard,
  • Sumei Lu,
  • Kenyaita M. Hodge,
  • Alessandra Chesi,
  • James Pippin,
  • Neil Romberg,
  • Struan F. A. Grant,
  • Andrew D. Wells

DOI
https://doi.org/10.1038/s41467-020-17089-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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T cells are a major cell type involved in systemic lupus erythematosus (SLE). Here, the authors use promoter capture-C and ATAC-seq in human follicular T helper cells to identify SLE genes distant from GWAS loci (via 3D interaction) and validate the function of key regulatory elements and genes in vitro.