Clinical-pharmacological aspects of the safe use of medicines, causing prolongation of QT interval

Abstract

Specific aspects of manifestation of prolonged QT syndrome, developed during the use of drugs belonging to different pharmacological groups are discussed. It analyses data on dangerous combinations of drugs that prolong the QT interval. The combination of drugs with the possible and conditional risk of QT interval prolongation and other drugs, which can influence the activity of metabolizing isoenzymes cytochrome P450, require special care from physicians, especially in elderly patients. Taking into account the possibilities of QT prolongation due to drug interactions it is recommended to avoid the use of potentially unsafe drug combinations.

Keywords

• синдром удлиненного интервала qt
• желудочковые аритмии
• взаимодействие лекарственных средств
• the long qt syndrome
• ventricular arrhythmias
• drug interactions