Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer

Abstract

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these kinases control proliferation, autophagy, cell survival, and cancer immune responses. Here we review the involvement of TBK1 and IKKε in controlling different cancers and in regulating responses to cancer immunotherapy.

Keywords

• TBK1
• IKKε
• innate immunity
• cancer signaling
• autophagy
• KRAS