Nature Communications (Jun 2020)
Hepatic HuR modulates lipid homeostasis in response to high-fat diet
- Zhuojun Zhang,
- Chen Zong,
- Mingyang Jiang,
- Han Hu,
- Xiaolei Cheng,
- Juhua Ni,
- Xia Yi,
- Bin Jiang,
- Feng Tian,
- Ming-Wen Chang,
- Wen Su,
- Lijun Zhu,
- Jinfan Li,
- Xueping Xiang,
- Congxiu Miao,
- Myriam Gorospe,
- Rafael de Cabo,
- Yali Dou,
- Zhenyu Ju,
- Jichun Yang,
- Changtao Jiang,
- Zhongzhou Yang,
- Wengong Wang
Affiliations
- Zhuojun Zhang
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Chen Zong
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Mingyang Jiang
- State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University
- Han Hu
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Xiaolei Cheng
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Juhua Ni
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Xia Yi
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Bin Jiang
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- Feng Tian
- Department of Laboratory Animal Science, Peking University Health Science Center
- Ming-Wen Chang
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Wen Su
- Department of Pathology, Shenzhen University Health Science Center
- Lijun Zhu
- Zhejiang Provincial Key laboratory of Pancreatic Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University
- Jinfan Li
- Department of Pathology, the Second Affiliated Hospital, School of Medicine, Zhejiang University
- Xueping Xiang
- Department of Pathology, the Second Affiliated Hospital, School of Medicine, Zhejiang University
- Congxiu Miao
- Institute of Reproduction and Genetics, Changzhi Medical College
- Myriam Gorospe
- Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health
- Rafael de Cabo
- Translational Gerontology Branch, National Institute on Aging, National Institutes of Health
- Yali Dou
- Department of Pathology and Biological Chemistry, University of Michigan
- Zhenyu Ju
- Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University
- Jichun Yang
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center
- Changtao Jiang
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center
- Zhongzhou Yang
- State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University
- Wengong Wang
- Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center
- DOI
- https://doi.org/10.1038/s41467-020-16918-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Human antigen R (HuR) is a RNA binding protein involved in the regulation of many cellular functions. Here the authors show that, hepatocyte specific deletion of HuR exacerbates high-fat diet-induced NAFLD in mice by regulating transcripts involved in lipid transport and ATP synthesis.
