The Influence of the Associated Inactivated Vaccine Against Infectious Rhinotracheitis and Bovine Viral Diarrhea on the Formation and Duration of Colostral Immunity in Kazakh Whiteheaded Calves
Yerbol Bulatov,
Alina Kurmasheva,
Zhanat Amanova,
Ruslan Abitaev,
Zhanna Sametova,
Asselya Kyrgyzbayeva,
Zhanat Kondybaeva,
Sholpan Turyskeldi,
Abdurakhman Ussembay,
Dariya Toktyrova,
Dana Mazbayeva,
Yeraly Shayakhmetov,
Aslan Kerimbayev,
Damir Khussainov,
Ma Wentao,
Aralbek Rsaliyev,
Yergali Abduraimov
Affiliations
Yerbol Bulatov
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Alina Kurmasheva
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Zhanat Amanova
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Ruslan Abitaev
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Zhanna Sametova
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Asselya Kyrgyzbayeva
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Zhanat Kondybaeva
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Sholpan Turyskeldi
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Abdurakhman Ussembay
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Dariya Toktyrova
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Dana Mazbayeva
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Yeraly Shayakhmetov
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Aslan Kerimbayev
Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy 080409, Kazakhstan
Damir Khussainov
Department of Veterinary and Zooengineering, Kazakh National Agrarian Research University, Almaty 050010, Kazakhstan
Ma Wentao
College of Veterinary Medicine, Northwest Agriculture and Forestry University, Xianyang 712100, China
Aralbek Rsaliyev
National Holding “QazBioPharm”, Astana 010000, Kazakhstan
Yergali Abduraimov
National Holding “QazBioPharm”, Astana 010000, Kazakhstan
Objectives: This article presents a study evaluating the antibody levels against infectious bovine rhinotracheitis (IBR) and bovine viral diarrhea (BVD) in Kazakh Whiteheaded calves born to dams immunized with an experimental inactivated combined vaccine against these infections. The vaccine formulation includes the strains “R-93” (IBR) and “Oregon C24V” (BVD), which are preserved in the microorganism collection of the Research Institute for Biological Safety Problems. Methods: To assess the immune response in newborn calves, blood serum samples were collected before the first intake of colostrum, followed by weekly sampling for 28 weeks post-birth. The antibody response was determined using a virus neutralization assay on MDBK cell cultures and lamb testicle cell cultures. Results: The results demonstrated that the protective antibody level against the IBR virus (≥2 log2) persisted for up to 25 weeks, while the protective level against the BVD virus (≥3 log2) remained for 23 weeks. Based on these findings, the vaccine was deemed safe, as it did not induce abortions or clinical manifestations of the diseases. The overall duration of the colostral immunity in calves against the IBR and BVD viruses reached 23 weeks. Conclusions: Therefore, it is recommended that Kazakh Whiteheaded calves be vaccinated with the associated inactivated vaccine against infectious bovine rhinotracheitis and bovine viral diarrhea no earlier than 23 weeks of age.
